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Quick Details

  • CAS No.: 436
  • Place of Origin: Vietnam
  • Type: Antibiotic and Antimicrobial Agents
  • Grade Standard: Medicine Grade

Packaging & Delivery

Packaging Details: 20 sachets/box x 100 boxes/carton
Delivery Detail: 60 days

Specifications

Mecefix B.E 75- Cefixim is indicated for the treatment of infections

COMPOSITION: Each sachet (1.5g) contains:
Cefixime................ 75 mg

DOSAGE FORM: Granule

PAKAGING: Box of 20 sachets

INDICATIONS
• Cefixime is indicated for the treatment of the following infections when caused by susceptible micro -
  organism.
• Upper respiratory tract infections: Bacterial pharyngitis, tonsillitis, otitis media, sinusitis.
• Lower respiratory tract infections: Acute bronchitis and acute exacerbations of chronic bronchitis.
• Uncomplicated urinary tract infections: Acute cystidis.
• Uncomplicated gonorrhoea.

 

DOSAGE AND ADMINISTRATIONS
Adults and children over 12 years
The recommended dosage is 200 - 400mg daily given either as a single dose or in two divided doses.
For upper respiratory tract infections and uncomplicated urinary tract infections: 200mg once daily.
In lower respiratory tract infections: 400mg daily is recommended.
For sinusitis: the therapeutic dosage must be administered for 10 to 14 days.
Treatment of uncomplicated Gonorrhoea: The recommended dosage is 400mg as a single oral dose.

Infants and childrens below 12 years of age
The recommended dosage is 8mg/kg daily given either as a single dose or in two divided doses.
In patients with more serious symptoms or unadequate effect, the dosage may increase to 6mg/kg,
  twice daily.

 

CONTRA - INDICATIONS
Cefixime is contra - indicated in patients with known allergy to the Cephalosporin group of antibiotics.

 

PRECATIONS
Precaution with patient has had previous hypersensitivity reactions to Cephalosporin, Penicillins. Rate of
  cross hypersensitivity among Beta - lactam antibiotics has been clearly documented and may occur in up
  to 10% of patients with a history of Penicillin allergy.
The possibility of the emergence of resistant organisms which might result in overgrowth should be kept in
  mind, particularly during prolonged treatment.
Cefixime should be prescribed with caution in individual with a history of gastrointestinal disease,
  particularly colitis.

 

USE IN PREGNANCY AND LACTATION
Pregnancy: Safe use in human pregnancy has not been established, only use real neccesarily.
Lactation: It is not known whether cefixime is excreted in human breast milk, only use real neccesarily.

 

SIDE - EFFECTS
Gastrointestinal: Diarrhoea, abdominal pain, dyspepsia, nausea and vomiting. Several cases of documented
  pseudomembraneous colitis were identified during the studies. The onset of pseudomembranous colitis
  symptoms may occur during or after therapy.
Hypersensitivity reactions: Skin rash, urticaria, drug fever, and pruritus. Erythema multiforme, Stevens -
  Johnson syndrome, and serum sickness-like reactions have been reported.
Hepatic: Transient elevation in SGPT, SGOT and alkaline phosphatase.
Renal: Transient elevations in BUN or Creatinine.
Central nervous system: Headaches or dizziness.
Hemic and Lymphatic systems: Transient thrombocytopenia, leukopenia, and eosinophilia. Prolongation
  in prothrombin time was seen rarely.
Other: Genital pruritus, vaginitis, candidiasis.

 

INTERACTIONS
Elevated carbamazepine levels have been reported when Cefixime is administered concomitantly.
A false - positive direct Coombs test has been reported during treatment with other cephalosporin antibiotics;
  therefore, it should be recognized that a positive Coombs test may be due to the drug.
Anticoagulants: Prolongation in clotting time was reported when using Cefixime with anticoagulants (Warfarin).

 

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